Originally refers to the actual dryness of bones, implying something is as dry as it can possibly be. The soil in the garden was bone dry, cracking underfoot.
Pro Tip 2/3
Exaggeration
Often used for emphasis to exaggerate the dryness of something, not always literally bone-level dry. His hands were bone dry after he wiped them thoroughly with a towel.
Pro Tip 3/3
Negative Connotation
Usually implies a negative situation, like drought or extreme thirst, which may be undesirable. The heatwave left the town's reservoirs bone dry.