This phrase implies a severe negative effect that threatens to stop something's normal function. The pandemic might bring the healthcare system to its knees.
Pro Tip 2/3
Figurative Sense
Used metaphorically, not literally. It's not about physical kneeling, but a collapse or failure. The cyber attack could bring the bank to its knees.
Pro Tip 3/3
Connotations of Crisis
The phrase often conveys a sense of crisis or emergency requiring urgent attention or action. Without urgent aid, famine will bring this region to its knees.