Come what may Definition 1 of 1Pro Tip 1/3Emotional Resolve Used to show determination in the face of uncertainty or difficulty. I'll finish this marathon, come what may. Pro Tip 2/3Future Uncertainties Implies readiness for unpredictable events in the future. We'll plan the picnic and, come what may, we'll have a great time. Pro Tip 3/3Support Loyalty Conveys unyielding support or commitment to a person or cause. I'll support your decision, come what may.