Stress that you're extremely uninterested or do not have any emotional investment in the situation. He's bragging about his new car, but I couldn't care less.
Pro Tip 2/3
Misinterpretation Alert
Be aware that 'could care less' is often mistakenly used, but it implies some level of interest. Remember, 'couldn't care less' means no interest at all!
Pro Tip 3/3
Casual Conversations
This phrase is usually appropriate in informal settings with friends but not in formal situations. In a meeting, say 'It's not a concern to me' instead of 'I couldn't care less.'