Depart from Definition 1 of 3Pro Tip 1/3Travel Plans Emphasizes the start of a trip or exit from a location, often used in travel itineraries. We will depart from the hotel at 8 AM sharp. Pro Tip 2/3Starting Point Refers to the physical place where a journey or action begins. The hiking group will depart from the trail's entrance. Pro Tip 3/3Concrete Locations Often precedes specific, named places rather than vague or general locations. The flight is scheduled to depart from Gate 23.