Game on Definition 1 of 3Pro Tip 1/3Challenge Initiation It often signals the start of a competitive interaction, not just a game. You've beaten my score? Game on! Pro Tip 2/3Enthusiastic Response Use it to show eagerness when accepting a challenge. They say I can't win this debate. Game on! Pro Tip 3/3Resuming Activity Signal the continuation of an event after a pause or interruption. The rain stopped, and the players returned. Game on!