The phrase can express strong annoyance, often used for repeated actions or habits. Her loud typing has really started to get on my nerves.
Pro Tip 2/3
Casual Context
This phrase is casual and might be inappropriate in formal contexts like business meetings. I wouldn't say my coworker's lateness gets on my nerves during a formal review.
Pro Tip 3/3
Personal Sensitivity
Using this phrase suggests a personal limit has been reached, rather than just casual annoyance. Can you please stop whistling? It's getting on my nerves.