Gnaw at Definition 1 of 2Pro Tip 1/3Emotional Impact Describes a process that causes continuous distress or harm over time. The insult from earlier was still gnawing at him hours later. Pro Tip 2/3Persistent Effect 'Gnaw at' indicates a gradual, often unnoticed problem that worsens. Rumors about the company's bankruptcy gnawed at the employees' morale. Pro Tip 3/3Metaphoric Use Metaphorically connects to the literal act of an animal chewing persistently. His failure in the exam gnawed at him, like a rodent on wood.