Use 'ill at ease' to describe discomfort due to specific surroundings or social settings. He was ill at ease at the crowded party.
Pro Tip 2/3
Emotional State
It can express a mild level of anxiety, not necessarily extreme fear or panic. She seemed ill at ease during the interview but managed to answer all the questions.
Pro Tip 3/3
Cultural Sensitivity
Remember that body language expressing discomfort varies by culture; 'ill at ease' reflects an internal feeling. Despite his smile, you could tell he was ill at ease.