Knock it off! Definition 1 of 1Pro Tip 1/3Informal Setting Use 'knock it off' in casual situations among friends or family. Guys, knock it off! We'll miss the movie. Pro Tip 2/3Not for Authority Avoid using 'knock it off' with superiors or formal contacts; it's too casual. N/A Pro Tip 3/3Frustration Expression It conveys irritation or annoyance. Say it when you're losing patience. If you don't knock it off, I'm leaving.