The phrase often suggests someone's reluctance or refusal to provide what is being asked for. Asking her for a favor is like getting blood out of a stone.
Pro Tip 2/3
Metaphorical Use
This phrase is never used literally. It's always a metaphor for difficult tasks or situations. Completing this project on time feels like getting blood from a stone.
Pro Tip 3/3
Negative Emotion
Using this phrase can express frustration or exasperation with the difficulty of the task. Getting him to admit his mistake was like getting blood from a stone.