
Long in the tooth
Often Humorous
The phrase is frequently used in a light-hearted or humorous way, rather than as a serious comment about someone's age. 
Informal Contexts
It's common in casual conversation among friends, but may be seen as impolite if used in formal situations or with strangers. 
Not Literal
The phrase isn't about teeth. It's a metaphor for someone's experience or tenure often coinciding with older age. 