Pick off Definition 1 of 3Pro Tip 1/3Skillful Action Suggests a swift and precise action, often done with care or expertise. She can effortlessly pick off the smallest bugs from her pet's fur. Pro Tip 2/3Negative Connotation Sometimes implies removing something unwanted or unpleasant. He quickly picked off the rotten berries from the bush. Pro Tip 3/3Focused Selection Indicates selecting or removing specific items among others. She carefully picked off the best apples from the tree.