Piss off Definition 1 of 2Pro Tip 1/3Informal Use Use 'piss off' casually with friends, but it's rude in formal settings. After the prank, Jake just laughed and told me to piss off. Pro Tip 2/3Forceful Dismissal 'Piss off' is often used to forcefully tell someone to leave immediately. I've had enough of your lies, now piss off! Pro Tip 3/3Anger Indicator Saying 'piss off' can show that you're angry or irritated with someone. When he kept teasing her, she shouted 'piss off!'