The phrase often signifies emotional reliance on others, highlighting a deep level of trust. He relied upon his friends to get through the tough times.
Pro Tip 2/3
Not Independent
Using 'rely upon' suggests that one can't manage without the help or support in question. I can't go to the event unless I can rely upon a ride from you.
Pro Tip 3/3
Responsibility
'Rely upon' can imply a sense of duty on the provider's part to not let the other down. Since the team relies upon my work, I'll stay late to finish it.