Run off Definition 1 of 4Pro Tip 1/3Urgent Departure Used to describe someone leaving quickly, often under pressure or in a rush. He ran off as soon as the bell rang. Pro Tip 2/3Avoiding Trouble Suggests escaping from a difficult situation or avoiding problems. She ran off when the argument started. Pro Tip 3/3Sudden Disappearance Indicates someone leaving suddenly without explanation. The magician ran off without a trace after the show.