Run off at the mouth
Definition 1 of 1
Pro Tip 1/3Colloquial Use
Used in informal situations among friends or in relaxed settings, not suitable for formal contexts. 
At the reunion, Mark started running off at the mouth about his wild college days.
Pro Tip 2/3Negative Connotation
Often implies disapproval; suggests a person talks too much or says inappropriate things. 
Our coach was frustrated with the team for running off at the mouth instead of focusing.
Pro Tip 3/3Emotional Trigger
Can indicate someone is under stress, excited, or nervous, which leads to excessive talking. 
During the interview, I was so anxious I started to run off at the mouth about irrelevant topics.