Seize upon Definition 1 of 2Pro Tip 1/3Act Quickly Emphasizes the speed and eagerness in taking action or deciding. He seized upon the last ticket to the concert. Pro Tip 2/3Positive Aggressiveness Shows a strong and positive determination to take an opportunity. She seized upon the chance to study abroad. Pro Tip 3/3Opportunistic Nuance Can suggest taking advantage of situations in a clever or resourceful way. The team seized upon their rival's weak defense.