Used in a light-hearted, humorous context, where you're poking fun but not hurting feelings. The comedian's act was a hilarious send up of politicians.
Pro Tip 2/3
Exaggeration Key
The imitation involves exaggeration and is not a direct copy of the subject being mocked. His send up of the rock star's stage antics had everyone rolling with laughter.
Pro Tip 3/3
Not Always Mean
While it mocks, 'send up' doesn't necessarily mean to be mean-spirited or offensive. She likes to send up horror movie clichés in her stories without being nasty.