This phrase often describes a strong negative emotional reaction, similar to hearing nails on a chalkboard. Listening to the screeching violin set my teeth on edge.
Pro Tip 2/3
Physical Sensation
Imagine the physical sensation of teeth clenching or grinding, indicating extreme irritation. Her loud gum-chewing really sets my teeth on edge.
Pro Tip 3/3
Exaggerated Effect
The phrase is often used to exaggerate for effect; the person is not literally annoyed to that extent. His bad jokes always set my teeth on edge, even though I laugh.