Sober up Definition 1 of 3Pro Tip 1/3Physical Recovery Refers to physically overcoming alcohol effects. It's a gradual process. After a long night, he needed time to sober up before heading home. Pro Tip 2/3Colloquial Usage Commonly used in casual speech among friends or in informal settings. She told her friend she'd sober up before the meeting. Pro Tip 3/3Immediate Responsibility Used when someone must quickly reduce drunkenness to be responsible or safe. He knew he had to sober up to drive his children home.