Strike out Definition 1 of 4Pro Tip 1/3Attempt Failure Used when someone tries hard but doesn't succeed, often in personal goals or careers. He struck out again trying to pass his driving test. Pro Tip 2/3Negative Outcome Implies an unsuccessful result, which can cause disappointment. Despite her efforts, she struck out in the talent audition. Pro Tip 3/3Subtle Frustration May convey a sense of frustration or setback without being too harsh. After three interviews, he struck out on getting the job.