Take it/a lot out of somebody
Definition 1 of 2
Pro Tip 1/3Physical Impact
Refers to literal fatigue after physical activities. 
Climbing that mountain really took it out of me.
Pro Tip 2/3Emotional Context
Used to describe emotional drain, not just physical tiredness. 
Dealing with the loss really took a lot out of her.
Pro Tip 3/3Not Negative Alone
Can describe the outcomes of positive events that are tiring. 
The wedding was wonderful, but it took a lot out of us.