The kiss of death Definition 1 of 3Pro Tip 1/3Negative Outcome Use when actions lead directly to failure, not just a small setback. Missing that deadline was the kiss of death for their project. Pro Tip 2/3Final Blow Emphasizes the last in a series of events that causes complete failure. The negative review was the kiss of death to the restaurant's reputation. Pro Tip 3/3Metaphoric Use Not a physical kiss, but symbolic of a destructive action or event. His endorsement turned out to be the kiss of death in the election.