The phrase often implies disappointment or frustration with someone's repeated actions. You're late again? There you go again, disregarding others' time.
Pro Tip 2/3
Colloquial Use
It's used in spoken language among friends or family, and not in formal situations. Forgot to turn off the lights? There you go again, wasting energy.
Pro Tip 3/3
Light Teasing
Can be used humorously among close ones, pointing out a harmless habit or quirk. Cookies gone already? There you go again, the cookie monster!