Tie one on Definition 1 of 1Pro Tip 1/3Colloquial Slang Used casually among friends, not in formal situations or with superiors. I can't wait for Friday to tie one on with the gang. Pro Tip 2/3Heavy Drinking Implies drinking a lot, more than just a casual drink. After his promotion, Joe decided to tie one on at the party. Pro Tip 3/3Celebratory Mood Often used when someone plans to celebrate or mark an occasion. It's her birthday tomorrow; she's definitely going to tie one on.