Indicates that someone's hard work or effort has failed to yield the desired results. She studied all night to little avail; the test was too difficult.
Pro Tip 2/3
Persistence Fails
Suggests that even persistent efforts have not led to success. He negotiated relentlessly to save the deal, but to little avail.
Pro Tip 3/3
Disappointment Implied
The phrase often conveys a sense of frustration or disappointment. They lobbied for the change to no avail, leaving them disappointed.