The phrase is mostly used by British speakers and could confuse others. They disliked the rainy weather, so they upped sticks to Spain.
Pro Tip 2/3
Colloquial Usage
Used in casual conversation, it might be too informal for official documents or formal writing. The city life was too chaotic for them, so they upped sticks to the countryside.
Pro Tip 3/3
Sudden Change
'Up sticks' implies a quick or sudden decision to leave, often with a sense of starting anew. After losing her job, Jenna decided to up sticks and start afresh elsewhere.