Implies concern or curiosity about someone's mood or behavior. What's with Sara? She's been sighing all morning.
Pro Tip 2/3
Not Literal
Doesn't always expect a serious answer, can be rhetorical to show surprise or confusion. What's with the suit? Are you meeting the president or something?
Pro Tip 3/3
Informal Context
Most appropriate in casual or informal situations, not for formal contexts. What's with the quietness, guys? We just scored a goal!