Used humorously to express skepticism or imply the subject is obscure, bizarre, or unfamiliar. He's an expert in cryptobiology, whatever that is when it's at home.
Pro Tip 2/3
Light Sarcasm
Implies playful sarcasm or irony, signaling you find what's mentioned odd or questionable. So you're a digital prophet now? What's that when it's at home?
Pro Tip 3/3
Colloquial Usage
It's informal and best used in casual conversation, not in formal or written contexts. She says she's a mixologist, whatever that is when it’s at home.