Wipe out Definition 1 of 4Pro Tip 1/3Complete Elimination Used when something is utterly destroyed, not just damaged or harmed. The fire wiped out the ancient forest. Pro Tip 2/3Hyperbolic Expression Sometimes used for emphasis or exaggeration, not literally. That exam totally wiped me out. Pro Tip 3/3Historical Events Often applied to tragedies like disasters or wars in history. A plague wiped out a third of the population.