Wise up Definition 1 of 2Pro Tip 1/3Colloquial Usage Best used in casual conversations rather than formal writing or professional settings. You need to wise up and see who your real friends are. Pro Tip 2/3Self-Improvement Often used to advise someone to improve their understanding or behavior. It's high time you wise up and work on your attitude. Pro Tip 3/3Emotional Connotation Can express frustration or impatience with someone's naivety or ignorance. Wise up, you're being completely unrealistic about the risks involved.