Degenerative/dɪˈdʒenərətɪv/ Definition 1 of 3Pro Tip 1/3Medical Context Used in healthcare topics to describe diseases that worsen over time. Her degenerative condition will require ongoing treatment. Pro Tip 2/3Irreversible Nature Implies the condition cannot improve and will continue to degrade. Degenerative diseases like Alzheimer's cannot be reversed. Pro Tip 3/3Aging Association Often linked to aging, reflecting conditions that deteriorate naturally over time. Age-related vision loss is a common degenerative problem.