Use 'enervate' when describing physical exhaustion or weakening, not just a lack of enthusiasm or boredom. Climbing the steep mountain trail enervated me before reaching the peak.
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Metaphorical Use
'Enervate' can be used metaphorically for things that cannot literally be tired, like an economy or a policy. The restrictive policies enervated the innovation drive in the company.
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Negative Connotation
'Enervate' carries a negative connotation, implying a reduction of effectiveness or strength. The scandal enervated the politician's chances of reelection.