Gout/ɡaʊt/ Definition 1 of 2Pro Tip 1/3Medical Condition Gout refers to a specific medical issue, not general pain or disease. My uncle was diagnosed with gout last year. Pro Tip 2/3Affected Areas Gout commonly affects joints, especially the big toe, not muscles. Gout has caused swelling in her big toe joint. Pro Tip 3/3Pain Intensity Gout causes intense pain, more than just discomfort or a mild ache. The gout flare-up left him in extreme pain.