Irremediably
/ˌɪrɪˈmiːdiəbli/
Definition 1 of 1
Pro Tip 1/3Irreversible Damage
Use 'irremediably' to describe a situation that can't go back to how it was. 
The ancient monument was irremediably altered by the earthquake.
Pro Tip 2/3Emphasize Finality
'Irremediably' adds weight to a statement, showing that something is beyond repair. 
His trust was irremediably shattered after the deception.
Pro Tip 3/3Strong Negative Feel
This word often carries a negative connotation, emphasizing loss or harm. 
Her reputation was irremediably tarnished by the scandal.