
Irrevocably
Finality Emphasized
Use 'irrevocably' when you want to stress that something has been changed so completely that there's no going back. 
Emotional Weight
'Irrevocably' adds a serious tone and often carries emotional weight, suggesting deep impact. 
Not Literal Only
Can describe figurative change, not just physical; relationships and situations can be 'irrevocably' affected. 