Melancholia/ˌmelənˈkəʊliə/ Definition 1 of 3Pro Tip 1/3Emotional Weight Melancholia implies a heavy, profound sadness, more than a fleeting feeling. His eyes reflected the melancholia of a man who had seen too much sorrow. Pro Tip 2/3Expressing Empathy Use melancholia when relating to someone's deep sadness to show empathy. I understood the melancholia she felt; losing a loved one is devastating. Pro Tip 3/3Avoid Casual Use Don't use 'melancholia' for everyday disappointments; it's too intense. Missing your favorite show doesn't warrant melancholia.