Mistrustful/ˌmɪsˈtrʌstfl/ Definition 1 of 1Pro Tip 1/3Negative Emotion Mistrustful has a negative tone, suggesting the person feels uneasy or wary. He gave a mistrustful stare at the unsolicited letter. Pro Tip 2/3Not Always Justified Being mistrustful doesn't mean there's actual evidence of wrongdoing, just suspicion. She was mistrustful of the offer, despite no apparent reason. Pro Tip 3/3Personal Relationships Often used when describing doubt within personal interactions or relationships. After the argument, he was mistrustful of her intentions.