Ointment/ˈɔɪntmənt/ Definition 1 of 3Pro Tip 1/3Medical Context Used mainly for substances in a medical or healing context, not just any cream. The doctor prescribed an antibiotic ointment for the burn. Pro Tip 2/3Topical Application Ointment is for external use, meant to be applied on skin surfaces rather than ingested. For the rash, only use the ointment externally. Pro Tip 3/3Thickness Contrast Generally thicker and greasier than creams or lotions, providing a protective barrier. Her dry hands needed a thick ointment, not just lotion.