Consider the context to determine if 'predisposition' refers to behavior or a health condition. His predisposition to migraines affects his daily routine.
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Often Genetic
'Predisposition' is frequently used to talk about genetic or hereditary tendencies. Twins may have a predisposition for similar behaviors.
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Not Absolute
Having a predisposition does not guarantee something will happen, it just increases likelihood. Despite her predisposition for artistic talent, she pursued a career in engineering.