Sclerotic/skləˈrɑːtɪk/ Definition 1 of 2Pro Tip 1/3Medical Context Used mainly in healthcare or biology to describe abnormal tissue hardening. He underwent surgery to remove the sclerotic areas in his arteries. Pro Tip 2/3Technical Term Often appears in medical literature and patient diagnoses, not in casual conversation. The MRI showed sclerotic plaques in the brain. Pro Tip 3/3Disease Association Commonly linked with chronic diseases like multiple sclerosis. Sclerotic features are consistent with progressive multiple sclerosis.