Secession/sɪˈseʃn/ Definition 1 of 3Pro Tip 1/3Political Context Secession is often linked to serious political disagreements and can lead to conflict. The secession of the region was met with military resistance. Pro Tip 2/3Historic Events Secession is a historic term, frequently tied to major events like the American Civil War. Secession is what sparked the American Civil War. Pro Tip 3/3Negative Connotation The term often implies a breakdown in relations and is seldom viewed positively. Governments often see secession as a threat to national unity.