Smallpox has been eradicated, so it's often discussed in a historical context. Smallpox was declared eradicated by the World Health Organization in 1980.
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Seriousness
Smallpox was a grave disease, discussing it should convey its severity. During the 18th century, smallpox was a devastating scourge across Europe.
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Medical Breakthrough
Refers to the vaccine as a historical medical breakthrough. The development of the smallpox vaccine was a turning point in fighting infectious diseases.