Spittle often implies disgust or disrespect when linked to spitting at someone or something. His angry speech was accompanied by spittle on the front row of the audience.
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Unintentional Action
'Spittle' can refer to saliva expelled accidentally while talking or laughing. She was laughing so hard that spittle sprayed from her mouth.
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Informal Usage
The term 'spittle' is less formal and can sound crude; 'saliva' is typically preferable in formal contexts. Please cover your mouth, I saw spittle as you yelled.