Spongiform/ˈspʌndʒɪfɔːrm/ Definition 1 of 1Pro Tip 1/3Medical Context Used mainly in medical settings to describe abnormal tissues. The biopsy showed spongiform changes consistent with the diagnosis. Pro Tip 2/3Technical Term It's a technical term and might be unfamiliar in everyday conversation. Her research focuses on spongiform diseases of the central nervous system. Pro Tip 3/3Disease Association Often linked to serious brain diseases, so it carries a grave tone. Creutzfeldt-Jakob disease is a fatal spongiform disorder.