Stupefy/ˈstuːpɪfaɪ/ Definition 1 of 3Pro Tip 1/3Not Literally Stupefy may not mean physically immobilize, but rather overwhelm someone's thoughts. The magician's act will stupefy the audience. Pro Tip 2/3Temporary Effect The effect of stupefying someone typically doesn't last long, it's momentary. The crowd was stupefied by the sudden fireworks. Pro Tip 3/3Neutral Tone Stupefy can be neutral and doesn't always suggest a negative impact. His impressive knowledge on the topic could stupefy anyone.