Systole/ˈsɪstəli/ Definition 1 of 2Pro Tip 1/3Heartbeat Phase Systole is when the heart squeezes to send blood out. My doctor explained that systole occurs before diastole. Pro Tip 2/3Pronunciation Clue Pronounce 'systole' with the stress on the first syllable: 'SIS-tuh-lee'. Correcting her mistake, she emphasized 'SIS' in 'systole'. Pro Tip 3/3Medical Context Systole is technical, used mainly by healthcare professionals. In the medical seminar, 'systole' was frequently mentioned.