Twinge/twɪndʒ/ Definition 1 of 3Pro Tip 1/3Physical Sensation Use 'twinge' to describe a brief moment of physical discomfort, not a long-lasting pain. After running, I sometimes feel a twinge in my knee. Pro Tip 2/3Sudden Occurrence 'Twinge' implies a pain that comes on suddenly, rather than gradually. She felt a twinge of pain when she twisted her ankle. Pro Tip 3/3Not Severe The pain described as a 'twinge' is usually not severe or debilitating. I only felt a slight twinge in my shoulder, nothing serious.