Twitchy/ˈtwɪtʃi/ Definition 1 of 2Pro Tip 1/3Often Negative Used to describe discomfort or unease, usually showing a negative emotion. During the silent exam, he looked twitchy and distracted. Pro Tip 2/3Collocations Matter Combines with 'feel' or 'look' to describe a person's state, often related to anxiety or stress. She always feels twitchy before public speaking. Pro Tip 3/3Stress Trigger Imagine situations that cause stress to understand when 'twitchy' might be used. Waiting for test results got him all twitchy.